Protein :Unlimited

Exploring unlimited Possibility in Protein Design

We are

Lab from University of science and Technology of China focusing on protein design

lab-liu photo

We are interested in

developing and applying computational tools for the study of structure, dynamics and interaction of biomolecules. One current focus is to develop efficient and accurate methods to simulate conformation equlibria in solution, and to apply such methods in force field improvements as well as in functional studies. Another focus is to improve protein design, including statistical energy functions, negative design and modular design.

To test and/or apply these tools, we collaborate with experimentalists (protein dynamics and conformational equilibria), or carry out experiments ourselves (protein sequence design) . For example, we are especially interested in designing highly focused sequence libraries for the efficient screening of new and specific molecular interactions. We are also attempting to integrate such designed/screened interactions with other molecular modules to create artificial signal-processing proteins that can be utilized in synthetic biological systems.

Research Area

Protein Design Enzymes Machine Learning Antibodies Directed evolution Assemblies Nanomachines protein interaction Mainchain Refinement IDP Small Peptide


Nov 11, 2022 Listen to the nature

go for picnic.

Aug 8, 2022 Graduate

Thanks to Prof.Liu and All the members.

Dec 19, 2022 Preprint

Deep learning SCUBA released.